Single-shot peripheral nerve blocks (sPNB) and continuous peripheral nerve blocks (cPNB) are cornerstone techniques in modern perioperative pain management. While sPNBs offer simplicity and effective short-term analgesia, their limited duration often leads to rebound pain as the block wears off. In contrast, cPNBs provide extended analgesia, reduce opioid consumption, and improve early recovery, albeit requiring more resources and careful management. Recent studies suggest cPNBs may mitigate rebound pain more effectively, though their role in preventing chronic postsurgical pain remains inconclusive. Within Enhanced Recovery After Surgery (ERAS) pathways, peripheral nerve blocks are broadly recommended to optimize recovery and reduce opioid exposure; however, neither technique is universally superior, and the choice must be tailored to surgical context and patient needs. This talk synthesizes current literature, pain trajectory models, and clinical cases to compare sPNB and cPNB across rebound pain, chronic pain risk, and ERAS integration. It advocates for an individualized, evidence-informed nerve block strategy in 2025 rather than one-size-fits-all solutions.